The primary functions of the gastrointestinal tract have traditionally been perceived to be limited to the digestion and absorption of nutrients, as well as electrolyte and water balance. A more attentive analysis of the structure and function of the GI tract, however, highlights another essential role: its ability to regulate the movement of substances between the external environment and the body through a barrier mechanism.
Alongside the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier—with its tight intercellular junctions—helps maintain balance between immune tolerance and immune response. When this barrier becomes compromised, a condition commonly referred to as “leaky gut,” inflammatory substances can enter the bloodstream and affect systems beyond the digestive tract.
There is increasing awareness that this loss of gut integrity may contribute to both intestinal and systemic symptoms, including those related to mood and behavior. Disruptions in gut health have been linked to chronic stress, neurotransmitter imbalances, brain fog, fatigue, anxiety, and immune dysregulation.
Danelle DeBye, NP, emphasizes that leaky gut is not just a gastrointestinal issue—it’s often a sign of deeper nervous system dysregulation and emotional stress that have gone unprocessed in the body. Her integrative approach addresses gut restoration, nervous system support, and root-cause healing to help individuals reclaim energy, focus, and emotional balance.
Danelle DeBye public briefing “Anxiety: It is not all in your head” at Barrington Public Library. Sponsored by BlueSkiesRI, East Bay Recover Center, Warren Prevention Coalition, and Warren Health Equity Zone.
April 17, 2025
